Active Research Trials
Here is a current list of our active trials over the three sites of the Newcastle Clinical Research Facility (last updated June 2021):
An observational, single-arm study of skeletal muscle metabolism in patients with rheumatoid arthritis receiving Tofacitinib.
123I-MIGB Scintigraphy Utility as a biomarker for Prodromal Dementia with Lewy Bodies (SUPErB)
7Tesla MRI Scanning in Alzheimer’s disease and Frontotemporal Lobar Degeneration
A 12 Week, Randomised, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Safety and Efficacy of Relamoreline in Patients with Diabetic Gastroparesis
A 2 year post market clinical follow up of a composite Single Visit Crown. Comparing a novel indirect workflow to an established direct workflow: A pilot study
A 24-month Phase II Open-label, Multicenter Long-term Extension Study to Assess the Long-term Safety and Efficacy of Vamorolone in Boys with Duchenne Muscular Dystrophy (DMD)
A 2-year Prospective Study to Assess Health-related Quality of Life in Subjects with Highly-Active Relapsing Multiple Sclerosis Treated with Mavenclad®
A Double-Blind, Placebo-Controlled, Multicentre Study with an Open-Label Extension to Evaluate the Efficacy and Safety of SRP-4045 and SRP-4053 in Patients with Duchenne Muscular Dystrophy
A MULTICENTER, OPEN-LABEL EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY AND TOLERABILITY OF FARICIMAB IN PATIENTS WITH DIABETIC MACULAR EDEMA
A Multi-Center, Prospective, Pragmatic, Randomized, Controlled Clinical Trial to Compare HF10 Therapy to Conventional Medical Management in the Treatment of Non-Surgical Refractory Back Pain
A Multicenter, Randomized, Double-Blind, Placebo Controlled 52-Week Maintenance and an Open-Label Extension Study of the Efficacy and Safety of Risankizumab in Subjects with Crohn’s Disease Who Responded to Induction Treatment in M16-006 or M15-991 Incorporating Administrative Change 1 and Amendment 1 and 2
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Maintenance and Long-Term Extension Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects with Crohn’s Disease who Completed the Studies M14-431 or M14-433
A multi-centre evaluation of excessive saliva management in patients with motor neurone disease.
A multi-centre evaluation of the post-gastrostomy management in patients with motor neurone disease
A multicentre randomised active controlled double-blind double dummy parallel group clinical trial investigating the efficacy, safety and tolerability of continuous subcutaneous ND0612 infusion in comparison to oral IR-LD/CD in subjects with Parkinson’s Disease experiencing motor fluctuations (BouNDless)
A Multicentre, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeuticsfor the Treatment of COVID-19 in Hospitalised Adults
A Multi-centre, Double-blind, Randomised, Placebo-controlled, Parallel-arm Phase IIa Trial to Evaluate the Efficacy, Safety and Tolerability of 28-Day Oral Treatment with PXT002331 (foliglurax) in Reducing Motor Complications of Levodopa Therapy in Subjects with Parkinson’s Disease Experiencing End-of-dose Wearing Off and Levodopa-Induced Dyskinesia (AMBLED)
A Multicentre, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Phase 3 Study to Evaluate the Efficacy and Safety ofBenralizumab 100 mg in Patients with Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) with a History of Frequent COPD Exacerbations and Elevated Peripheral Blood Eosinophils (RESOLUTE)
A Multicentre, Randomized, Double-Blind, Placebo-Controlled 52-Week Maintenance and an Open-Label Extension Study of the Efficacy and Safety of Risankizumab in Subjects with
A Multicentre, Randomized, Double-Blind, Placebo-Controlled Induction Study of the Efficacy and Safety of Risankizumab in Subjects with Moderately to Severely Active Crohn’s Disease
A Multicentre, Randomized, Double-Blind, Placebo-Controlled Induction Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects with Moderately to Severely Active Crohn’s Disease who have Inadequately Responded to or are Intolerant to Biologic Therapy
A Multicentre, Randomized, Double-Blind, Placebo-Controlled Induction Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects with Moderately to Severely Active Crohn’s Disease Who Have Inadequately Responded to or are Intolerant to Conventional Therapies but Have Not Failed Biologic Therapy.
A Multicentre, Randomized, Double-Blind, Placebo-Controlled Induction Study to Assess the Efficacy and Safety of Risankizumab in Subjects with Moderately to Severely Active Crohn’s Disease Who Failed Prior Biologic Treatment
A Multicentre, Randomized, Double-Blind, Placebo-Controlled Induction Study to Evaluate the Efficacy and Safety of Risankizumab in Subjects with Moderately to Severely Active Ulcerative Colitis Who Have Failed Prior Biologic Therapy
A Multicentre, Randomized, Double-Blind, Placebo-Controlled Study in Subjects With Relapsing Multiple Sclerosis to Evaluate the Efficacy and Safety of BIIB033 as an Add-On Therapy to Anti-Inflammatory Disease-Modifying Therapies (AFFINITY)
A Multicentre, Randomized, Double-Blind, Placebo-Controlled Study, with an Active-Treatment Dose-Blinded Period, to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Subjects with Parkinson’s Disease.
A multimodal imaging study to improve early diagnostic accuracy in patients with Parkinsonian disorders and idiopathic REM sleep behaviour disorders
A multinational, multicentre, prospective non-interventional study to assess safety and effectiveness of opicapone plus standard of care in elderly patients with Parkinson’s Disease
A Phase 1/2 trial on the safety, tolerability, pharmacokinetics, pharmacodynamics and exploratory efficacy of DYN101 in patients ≥ 16 years of age with centronuclear myopathies caused by mutations in DNM2 or MTM1.
A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Proof of Concept Study to Evaluate the Efficacy and Safety of VIB4920 in subjects with Sjogren’s Syndrome (SS)
A Phase 2 Study of ABBV-3067 Alone and in Combination with ABBV-2222 in Cystic Fibrosis Subjects Who Are Homozygous for the F508del Mutation
A phase 2 study to investigate the safety and efficacy of ABBV-105 given alone or in combination with a background of conventional synthetic DMARDS in subjects with active Rheumatoid Arthritis with inadequate response to or intolerance to biological DMARDS.
A Phase 2, 24-Week, Randomized, Double-blind, Placebo-controlled, Multicentre Study, With an 80-Week Active Treatment Extension, to Evaluate the Efficacy and Safety of CC-90001 in Subjects With Idiopathic Pulmonary Fibrosis
A phase 2/3 study to determine the efficacy, safety and immunogenicity of the candidate Coronavirus Disease (COVID-19) vaccine ChAdOx1 nCoV-19
A Phase 2b, Multicentre, Multinational, Placebo-controlled, Double-blind, Dose-finding Study in Adult Patients with Type I, III or IV Osteogenesis Imperfecta Treated with BPS804
A PHASE I/II RANDOMIZED, TWO PARTS, DOSE-FINDING STUDY TO EVALUATE THE SAFETY, TOLERABILITY AND IMMUNOGENICITY OF AN INACTIVATED, ADJUVANTED SARS-COV-2 VIRUS VACCINE CANDIDATE (VLA2001), AGAINST COVID-19 IN HEALTHY SUBJECTS
A Phase Ib/IIa, randomized, double-blind placebo-controlled, multicentre adaptive design clinical trial to evaluate the immune signature of the treatment with the Imotope™ IMCY- 0098 and its effect on the preservation of beta-cell function in young adult and adolescent patients with a recent onset Type 1 diabetes
A PHASE II OPEN-LABEL EXTENSION STUDY TO EVALUATE THE LONG-TERM SAFETY AND TOLERABILITY OF UTTR1147A IN PATIENTS WITH MODERATE TO SEVERE ULCERATIVE COLITIS OR CROHN’S DISEASE
A phase II randomised placebo controlled double blinded trial of Interleukin 1 blockade in Acute Severe Colitis
A PHASE II, RANDOMIZED, PARALLEL-GROUP, DOUBLE-BLIND, DOUBLEDUMMY, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY, SAFETY, AND PHARMACOKINETICS OF UTTR1147A COMPARED WITH PLACEBO AND COMPARED WITH VEDOLIZUMAB IN PATIENTS WITH MODERATE TO SEVERE ULCERATIVE COLITIS
A Phase IIb double-blind, randomised, placebo controlled, multi-centre, confirmative three-way cross over study on cognitive function with two doses of KH176 in subjects with a genetically confirmed mitochondrial DNA tRNALeu(UUR) m.3243A>G mutation.
A Phase IIb, Double Blind, Placebo Control, Dose Ranging, Parallel Groups, Randomized Study to Assess Safety and Tolerability, efficacy and Pharmacokinetics of VBP15 in boys with Duchenne Muscular Dystrophy
A Phase III Double-blind, Randomized, Placebo-Controlled Study assessing the Efficacy, Safety and Tolerability of Idebenone in Patients with Duchenne Muscular Dystrophy Receiving Glucocorticoid steroids.
A PHASE III, MULTICENTER, RANDOMIZED, DOUBLE-MASKED, ACTIVE COMPARATOR-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF FARICIMAB IN PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
A Phase III, Multicentre, Randomised, Double-Masked, Active Comparator Controlled Study to Evaluate the Efficacy and Safety of R06867461 in Patients with Diabetic Macular Edema
A Phase III, Multicentre, Randomized, Parallel Group, Double Blind, Double Dummy, Active Controlled Study of Evobrutinib Compared with Teriflunomide, in Participants with Relapsing Multiple Sclerosis to Evaluate Efficacy and Safety.
A Phase III, Randomised, Double-Blind, Placebo-Controlled, Multicentre Study to Evaluate Safety and Efficacy of Octreotide Capsules in Patients who Previously Tolerated and Demonstrated Biochemical Control on Injectable Somatostatin Receptor Ligands (SRL) Treatment
A Phase Ill, randomized, multicentre, open-label, non-inferiority study evaluating the efficacy, safety and tolerability of switching to dolutegravir/ lamivudine fixed dose combination in HIV-1 infected adults who are virologically suppressed
A Pivotal Randomized Study Assessing Vagus Nerve Stimulation (VNS) During Rehabilitation for Improved Upper Limb Motor Function After Stroke (VNS-REHAB)
A Placebo-controlled double blind parallel group randomised study to evaluate the efficacy safety, and tolerability of E2027 in subjects with dementia lewy bodies
A prospective double blind randomised controlled study to evaluate the immunological benefits and clinical effects of an elimination diet using an amino acid formula (AAF) with an added preprobiotic blend in infants with Cow’s Milk Allergy (CMA).
A proSpective randomized controlled trial comParing infliximAb-antimetabolites combination therapy to anti-metabolites monotheRapy and infliximab monothErapy in Crohn’s disease patients in sustained steroid-free remission on combination therapy (SPARE)
A prospective, observational, UK study to describe the quality of life, patient reported outcomes in relapsing remitting multiple sclerosis patients treated with Aubagio (teriflunomide) 14 mg in a routine clinical practice.
A Randomised Controlled Trial investigating the feasibility of a multi-domain intervention to increase Mediterranean Diet (MedDiet) Score and Physical Activity (PA) of older UK adults who are at above average risk of dementia
A randomised controlled trial of acceptance and Commitment therapy for people with Motor nEuroN Disease (COMMEND)
A randomised controlled trial of Specialist Physiotherapy for Functional Motor Disorder (Physio4FMD)
A Randomised double blind placebo controlled phase 2 study of safety tolerability and efficacy of pirfenidone in patients with Rheumatoid arthritis interstitial lung disease.
A Randomised, Double-Masked, Placebo-Controlled Exploratory Study to Evaluate Safety, Tolerability, Pharmacodynamics and Pharmacokintecis of orally administered BI 1467335 for 12 weeks with a 12 week follow up period in patients with non-proliferative diabetic retinopathy without centre-involved diabetic macular edema
A randomized, double blind (sponsor open), comparative, multicentre study to evaluate the safety and efficacy of subcutaneous belimumab (GSK1550188) and intravenous rituximab coadministration in subjects with primary Sjögren’s syndrome.
A Randomized, Double-blind, Placebo-controlled Phase 3 Study to Assess the Efficacy and Safety of Ad26.COV2.S for the Prevention of SARS-CoV-2-mediated COVID-19 in Adults Aged 18 Years and Older
A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY EVALUATING THE EFFICACY AND SAFETY OF SAGE-217 IN THE TREATMENT OF ADULTS WITH SEVERE POSTPARTUM DEPRESSION
A Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Varying Doses and Dose Regimens of Evinacumab in Patients with Persistent Hypercholesterolemia Despite Maximally Tolerated Lipid Modifying Therapy
A Randomized, Double-Blind, Placebo-Controlled, Dose Finding Study to Evaluate the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-Onset Seizures in Adult Subjects with Drug- Resistant Epilepsy
A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Safety, Tolerability and Efficacy of XEN1101 as Adjunctive Therapy in Focal-onset Epilepsy.
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Intravenously Administered BMS-986168 in Participants with Progressive Supranuclear Palsy
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicentre Study to Evaluate the Effects of SOtagLiflozin on Clinical Outcomes in HemOdynamIcally STable Patients with Type 2 Diabetes POST Worsening Heart Failure
A randomized, double-blind, placebo-controlled, parallel-group, multicentre, event-driven Phase III study to investigate the efficacy and safety of finerenone, in addition to standard of care, on the progression of kidney disease in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disease
A randomized, double-blind, placebo-controlled, phase II, cross-over clinical trial evaluating the efficacy and safety of KVD900, an oral plasma kallikrein inhibitor, in the on-demand treatment of angioedema attacks in adult subjects with hereditary angioedema type I or II
A Single Arm Multiple Dose Study to Assess the Efficacy and Safety of ANB019 in Subjects with Generalized Pustular Psoriasis
A SINGLE ARM, OPEN LABEL MULTICENTRE EXTENSION STUDY TO EVALUATE THE EFFECTIVENESS AND SAFETY OF OCRELIZUMAB IN PATIENTS WITH MULTIPLE SCLEROSIS PREVIOUSLY ENROLLED IN A F. HOFFMANN-LA ROCHE SPONSORED OCRELIZUMAB PHASE IIIb/IV CLINICAL TRIAL
A subject-, investigator-, and sponsor-blinded, randomized, placebo-controlled, multicentre study to investigate efficacy, safety, and tolerability of VAY736 in patients with idiopathic pulmonary fibrosis
A two-part randomized, double-blind, placebo-controlled multicentre dose ranging and confirmatory study to assess the safety and efficacy of VAY736 in autoimmune hepatitis patients with incomplete response to or intolerance of standard therapy(AMBER)
Acceptability and clinical trial feasibility evaluation of auditory rhythmical cueing to improve gait and physical activity in community dwelling stroke survivors
ACCORD 2: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID 19 in Hospitalised Patients
Adjuvant rituximab: A potential treatment for the young patient with Graves’ hyperthyroidism.
Advanced applications of ocular coherence tomography
An Eighteen-Month, Two-Arm, Randomized, Double-Masked, Multicenter, Phase III Study Assessing the Efficacy and Safety of Brolucizumab versus Aflibercept in Adult Patients with Visual Impairment due to Macular Edema secondary to Central Retinal Vein Occlusion
An International natural history study of dysferlinopathy
An International, Prospective Registry Investigating the Natural History of Children with Achondroplasia
An interventional, randomised ,double blinded parallel group, placebo controlled, phase 1a/1b, single site study to assess the safety and tolerability and pharmacokinetics of KL1333 after oral multiple ascending doses in male and female health volunteers and patients with genetically confirmed inherited mitochondrial respiratory chain disease.
An Open Label Long-Term Study to Evaluate the Safety and Tolerability of Seladelpar in Subjects with Primary Biliary Cholangitis (PBC)
An open label phase I/IIa trial repurposing carbamazepine (CBZ) for the treatment of skeletal dysplasia in children.
An open label, active comparator extension trial to assess the effect of long term dosing of inclisiran and evolocumab given as subcutaneous injections in subjects with high cardiovascular risk and elevated LDL-C (ORION-3)
An open non-randomised pilot study to assess acceptability and feasibility of an internet / mobile phone enhanced service pathway for the prevention and management of type 2 diabetes.
An Open-Label Extension And Safety Monitoring Study Of Moderate To Severe Ulcerative Colitis Patients Previously Enrolled In Etrolizumab Phase III Studies
AN OPEN-LABEL EXTENSION AND SAFETY MONITORING STUDY OF PATIENTS WITH MODERATELY TO SEVERELY ACTIVE CROHN’S DISEASE PREVIOUSLY ENROLLEDIN THE ETROLIZUMAB PHASE III PROTOCOL GA29144
An open-label study to evaluate the safety and tolerability of 12 weeks treatment with oral REN001 in patients with primary mitochondrial myopathy (PMM), with an optional extension of treatment
AN OPEN-LABEL STUDY TO INVESTIGATE THE SAFETY, TOLERABILITY, AND PHARMACOKINETICS/PHARMACODYNAMICS OF RO7034067 IN ADULT AND PEDIATRIC PATIENTS WITH SPINAL MUSCULAR ATROPHY
An open-label, multicentre, multinational extension study of the long-term safety and pharmacokinetics of repeated biweekly infusions of neoGAA in patients with Pompe disease
AN OPEN-LABEL, SINGLE-ARM STUDY TO EVALUATE THE EFFECTIVENESS AND SAFETY OF OCRELIZUMAB IN PATIENTS WITH EARLY STAGE RELAPSING REMITTING MULTIPLE SCLEROSIS
AN OPEN-LABEL,MULTICENTER, ROLLOVER STUDYTO EVALUATE THE SAFETY AND TOLERABILITY OF LONG-TERM ADMINISTRATION OFGANTENERUMABIN PARTICIPANTSWITHALZHEIMER’S DISEASE
Arthritis Prevention In The Pre-clinical Phase of RA with Abatacept
Assessing cognitive impairment in Primary Biliary cirrhosis
Assessing pulmonary ventilation and perfusion properties with MRI
Assessing seizure susceptibility using psychophysical tests
BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study)
Biology of Juvenile Myoclonic Epilepsy
Clinical and genetic determinants of disease progression and response to lifestyle intervention in patients with hypertrophic cardiomyopathy
Clinical Characterisation Protocol for Severe Emerging Infection
Collection of White Blood Cells [Using Leukapheresis] from Rheumatoid Arthritis Patient’s for the Validation of an Advanced Treatment for Rheumatoid Arthritis (tolDC)
Comprehensive Outcomes Registry in Subjects with Epilepsy Treated with Vagus Nerve Stimulation Therapy®
Conservative iron chelation as a disease-modifying strategy in Parkinson’s disease.
Controlling Abnormal Network Dynamics using Optogentics (CANDO): The role of structural and functional connectivity and high frequency oscillations in the prediction of outcomes in epilepsy surgery
COVID-19 Emergency Response Assessment (CERA)
DECIDE study: Dental ExtraCtions versus fillings for adult teeth In children: a cost bEnefit/effectiveness analysis
Defining delirium and its impact in Parkinson’s Disease(DELIRIUM-PD)
Dementias Platform UK MR-PET network harmonisation study
Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage
Determination of relative bioavailability, bioconversion and bio efficacy of β-cryptoxanthin in comparison to β-carotene from biofortified maize and external stable isotopes using compartmental modelling.
Develop objective assessment tools for measuring fatigue in clinical studies
Developing a Core Outcome Set for hospital deprescribing trials: a modified Delphi study (CHARMER)
Developing a dynamic FDG-PET/MR imaging methodology to study gait in ageing and neurodegenerative disease
Development of a diagnostic and therapeutic response biomarker for patients with rheumatoid arthritis
Development of a Nano-biosensor to Monitor Periodontal Inflammation
Development of translational biomarkers of glutamate dysfunction in brain tumour related epilepsy
DexEnceph: A pragmatic, randomised, controlled, observer blind trial comparing clinical outcomes in adults who receive dexamethasone alongside standard treatment versus standard treatment alone for Herpes Simplex Virus encephalitis.
Diabetes and periodontitis: development of oral health initiatives to improve glycaemic control.
Duchenne muscular dystrophy: double blind randomized trial to find optimum steroid regimen
Early low dose steroids for adults admitted to hospital with influenza-like illness during a pandemic: a randomised placebo controlled trial
Early Valve Replacement guided by Biomarkers of Left Ventricular Decompensation in Asymptomatic Patients with Severe Aortic Stenosis
Enhancing Dental Treatment Decisions for People Living with Dementia
Epigenetic Regulation of Gene Expression in Primary Sjogren’s Syndrome
Establishment of optimised biomedical and psychosocial outcome measures following islet cell transplantation.
Evaluation of the prognostic potential and functional significance of biomarkers in oral cancer
Evaluation of the role of tongue base MucOsectomy and Step sErial Sectioning in the management of the unknown primary squamous cell cancer in the head and neck
Ex-Vivo thrombogenicity evaluation of the polymeric prosthetic heart valve from anisotropic nanocomposites
Feeding Late and Moderately Preterm Infants Nutrition and Growth Outcomes (FLAMINGO)
GALACTIC-1 – A randomised, double-blind, multicentre, parallel, placebo controlled Phase 2B study in subjects with idiopathic pulmonary fibrosis (IPF) investigating the efficacy and safety of TD139, an inhaled galectin-3 inhibitor administered via a dry powder inhaler over 52 weeks.
Glutamate dysfunction in glioma – correlating Magnetic resonance spectroscopy with ex-vivo electrophysiology
GRADUATE – Gantenerumab in patients with prodromal to mild AD
Health Effects of Medical Radiation Exposures
Healthcare resource utilisation in patients with Parkinson’s disease after treatment with entacapone and opicapone study
IBIS-II DCIS: An international multicentre study of Anastrozole vs Tamoxifen in Postmenopausal Women with Ductal carcinoma in Situ (DCIS)
Identification of disease susceptibility genes associated with development and clinical characteristics of primary inflammatory muscle diseases, PM, DM and IBM
Identifying candidate digital measures for the assessment of sleep and fatigue in the home environment
Identifying Predictors of dementia with Lewy bodies in People with Mild Cognitive Impairment
Identifying the Biological Fingerprints of Fatigue
IDL-2965 – A Phase I, Randomized, Double-blind, Placebo-controlled, Single and Multiple Oral Dose, Safety, Tolerability, and Pharmacokinetic Study in Healthy Subjects and Subjects with Idiopathic Pulmonary Fibrosis
Improving the Clinical Characterisation of BDR (BDR3 Programme)
Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation – Parkinson’s Disease
Inhibition of Co-Stimulation in Rheumatoid Arthritis
Interrogating mitochondrial dysfunction in facial appearance and ageing
Intravenous immunoglobulin and intravenous methylprednisolone as optimal induction treatment in CIDP
Investigating the impact of symptomatic irreversible pulpitis on quality of life, and the effectiveness of different management strategies: An observational study
Investigation of factors influencing arthritis and response to therapy with biologic drugs
IT’S NOT JUST IDIOPATHIC PULMONARY FIBROSIS STUDY
Laboratory-based investigations on dental hard and soft tissues
Leigh syndrome: Investigating Outcome measures & Natural history (LION) – a prospective, longitudinal cohort study
Lifestyle as Therapy in Liver Disease
Lifestyle in Later Life of older people living with frailty and multiple long-term conditions attending an Older People’s Medicine service: feasibility and acceptability study
Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS): Assessment & Validation of Imaging Modality Performance across the NAFLD Spectrum in a Prospectively Recruited Cohort
Long term observational extension study of gonadal function after pubertal induction in Duchenne Muscular Dystrophy
Long-term, Open-label Extension Study for Patients with Duchenne Muscular Dystrophy Enrolled in Clinical Trials Evaluating Casimersen or Golodirsen
LRRK2 International Parkinsons Disease Program: An International, multicentre, epidemiological observational study
MASS_Lifecourse: Establishing a life course cohort for advances in the prevention, diagnosis and treatment of sarcopenia.
Maternal and Perinatal Outcomes of Pandemic Influenza in Pregnancy
Medical Research Council Centre for the Neuromuscular diseases: Mitochondrial disease patient cohort study
Men’s Ageing Muscle and Anti-retroviral study
Mitochondrial Donation: Outcome at 18 months
Motor unit assessment with magnetic resonance imaging. A new way to measure and understand the pathophysiology of amyotrophic lateral sclerosis
MR imaging of motor unit dynamics as a non-invasive disease biomarker in spinal muscular atrophy and amyotrophic lateral sclerosis
Multiarmed Therapeutic study in pre-ICU patients admitted with COVID-19 – Repurposed Drugs
Multicentre, randomized, placebo-controlled, double-blind, parallel group, dose-finding Phase 2 study to evaluate efficacy and safety of BAY 2433334 in patients following an acute Non cardioembolic ischemic stroke
MULTINATIONAL, MULTICENTRE, PROSPECTIVE, OPEN-LABEL, UNCONTROLLED CLINICAL TRIAL TO ASSESS THE EFFICACY AND SAFETY OF AUTOLOGOUS CULTIVATED LIMBAL STEM CELLS TRANSPLANTATION (ACLSCT) FOR RESTORATION OF CORNEAL EPITHELIUM IN PATIENTS WITH LIMBAL STEM CELL DEFICIENCY DUE TO OCULAR BURNS (HOLOCORE)
Muscle and Ageing Science Study in Parkinson’s Disease (MASS_PD): What is the role of skeletal muscle dysfunction in Parkinson’s disease?
Muscle disease progression in mitochondrial DNA deletions
Neuromuscular Rare Disease Translational Research in patients with Duchenne Muscular Dystrophy
Neurophysiology of functional neurological disorder
NIHR BioResource Centre Newcastle and NIHR BioResource(Part of NIHR BioResource for Translational Research in Common and Rare Diseases)
Open label, long-term safety, tolerability, and efficacy study of GIVINOSTAT in all DMD patients who have been previously treated in one of the GIVINOSTAT studies.
Oral Health in People with Learning Disabilities: Exploring the views of stakeholders in North East England to inform local service (re)design
Overcoming the barriers to maximise the commercial potential of vitamin D-enriched eggs.
Perindopril and Leucine to improve muscle function in older people. (LACE Study)
Personalised Nutrition in Non-Alcoholic Fatty Liver Disease: Feasibility of a Nutrigenomic Therapeutic Approach
Personalised ultraviolet B (UVB) treatment of psoriasis through biomarker integration with computational modelling of psoriatic plaque resolution.
Fibrosis with Nalbuphine ER Tablets for the Treatment of Cough
Phase 3, open label, single arm study to evaluate efficacy and safety of FIX gene transfer with PF-06838435 (rAAV-Spark100-hFIX-Padua) in adult male participants with moderately severe to severe haemophilia B
Phase 3b Open-Label, Multicentre, Safety Study of BIIB037 (aducanumab) in Subjects with Alzheimer’s disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205
PHASE 3B/4 RANDOMIZED SAFETY ENDPOINT STUDY OF 2 DOSES OF TOFACITINIB IN COMPARISON TO A TUMOR NECROSIS FACTOR (TNF)INHIBITOR IN SUBJECTS WITH RHEUMATOID ARTHRITIS
Phase III, Open-Label, Single Arm, Single Dose Gene Replacement Therapy Clinical Trial for Patients with Spinal Muscular Atrophy Type 1 with One or Two SMN2 Copies Delivering AVXS-101 by Intravenous Infusion
Phase III, randomized multicentre double-blind, double-dummy study to evaluate the efficacy and safety of Etrolizumab compared with Infliximab in patients with moderate to severe active Ulcerative Colitis who are Naive to TNF Inhibitors.
Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes
Predicting the progression of m.3243A>G-related mitochondrial disease using white blood cell heteroplasmy
Predicting which Children with complete Unilateral Cleft Lip and Palate will have poor mid face growth using a data mining computational analysis of 3-D dental arch models of infants.
PRoBaND: Parkinson’s Repository of Biosamples and Network Datasets: Prospective observational study of Parkinson’s disease with repeat clinical assessment and biobanking of blood samples.
PROgressive Supranuclear Palsy CorTicoBasal Syndrome Multiple System Atrophy Longitudinal Study UK (PROSPECTMUK)
PRospective Observational Study of PatiEnts with mitochondrial depletion syndrome, RRM2B
Prospective, Longitudinal Study of the Natural History and Functional Status of Patients with Limb-Girdle Muscular Dystrophy 2I
Randomised double-blind controlled trial of connectivity guided theta burst transcranial magnetic stimulation versus repetitive transcranial magnetic stimulation for treatment resistant moderate to severe depression evaluation of efficacy, cost effectiveness and mechanism of action
Randomised Evaluation of COVID-19 Therapy (RECOVERY)
Randomised, double blind, placebo controlled, multicentre study to evaluate the efficacy and safety of givinostat in ambulant patients with Duchenne Muscular Dystrophy
Randomised, double-blind, placebo-controlled, parallel-group, multi-centre, phase III trial to investigate the efficacy, safety and tolerability of Naloxone HCl PR Tablets in patients with opioid induced constipation
Randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in patients with Mitochondrial Myopathy
Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of BHV-3241 in Subjects with Multiple System Atrophy
Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicentre, Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema following Large Hemispheric Infarction
Remission of type 2 diabetes (T2DM) with Total Diet Replacement and long-term maintenance, within routine NHS care
Reproducibility of heart rate variability measurements at rest and during exercise in healthy individuals
Resistance of human dental hard tissues to erosive wear and caries (donation of human teeth)
Reversal of Type 2 diabetes upon normalisation of energy intake in non-obese people (ReTUNE)
Safety, tolerability and pharmacokinetics of single rising intravitreal doses of BI 754132 in patients with geographic atrophy secondary to age-related macular degeneration (open label, nonrandomized, uncontrolled)
SALivary electro-stimulation for the treatment of dry mouth in patients with Sjogren’s syndrome: a multicentRe randomISEd sham-controlled double-blind study
Sensitivity and specificity of non-invasive cardiac output assessment to identify heart failure
SIGMuND; Stereotactic Image Guided Muscle Neurodiagnostic
Simvastatin as a neuroprotective treatment for Parkinson’s disease: a double-blind, randomised, placebo controlled futility study in patients of moderate severity
Study in Novel Neuro-muscular Imaging Biomarkers for Motor Outcome in Stroke
Study to determine the effect of ferric maltol on gut microbiota in inflammatory bowel disease patients with iron deficiency (NAHPB-122)
Targeting the Rheumatoid Arthritis Synovial Fibroblast via Cyclin Dependent Kinase Inhibition – an early phase trial (TRAFIC)
The Cholinergic ResponsE in Early lewy body Disease (CREED) Study
The influence of pre-meal whey protein on appetite and energy intake and free-living glycaemic control in type 2 diabetics: a randomised-control trial
The MAGIC trial (Melatonin for Anxiety prior to General anaesthesia In Children): A Multicentre, Parallel Randomised Controlled Trial of Melatonin Versus Midazolam in the Premedication of Anxious Children Attending for Elective Dental, Ophthalmologic or ENT Surgery Under General Anaesthesia
The neurobiological basis of gait dysfunction in Parkinson’s disease
The Parkinson’s Progression Markers Initiative (PPMI) 2.0 Clinical –
Establishing a Deeply Phenotyped PD Cohort
The PRIEST Study: Pandemic Respiratory Infection Emergency System Triage
The role of inflammation in human immunity
The UK Inflammatory Bowel Disease Bioresource: Progressing from Genetics to Function and Clinical Translation in Crohn’s Disease & Ulcerative Colitis
Tracking of risk for diabetic nephropathy and cardiovascular disease in young people with type 1 diabetes recruited to the AdDIT study
Treatment of Pustular Psoriasis with the IL-1 receptor antagonist anakinra: a randomised, placebo controlled trial and associated mechanistic studies (APRICOT)
TriMaster: Randomised Double-Blind Crossover study of a DPP4 inhibitor, SGLT2 inhibitor and thiazolidinedione as third line therapy in patients with type 2 diabetes who have suboptimal glycaemic control on dual therapy with metformin and a sulphonylurea
Understanding and Investigating Cerebellar Ataxia in Adult Mitochondrial Disease (Mito Ataxia)
Understanding mammalian biomineralisation in health and disease via a molecular dissection of the mechanisms underpinning Amelogenesis Imperfecta
Understanding the relationship between cognitive fluctuations, sleep and arousal in dementia with Lewy bodies (COG-SLEEP)
United Kingdom Primary Sjogren’s Syndrome Registry – Does fatigue in patients with primary Sjogren’s syndrome correlated with general disease activity and damage?
Using Next Generation Sequencing to Unravel the Pathogenesis of Sporadic Inclusion Body Myositis (IBM) International – IBM Consortium Genetic Study
Validating digital mobility assessment using wearable technology – The Mobilise-D Technical Validation study.
What can gait analysis tell us about dementia and its subtypes? An integrated study of brain and behaviour.